LIU Hongsheng, a professor and Dean of School of Pharmaceutical Science of Liaoning University, got Ph.D in Microbiology and Bioinformatics in 2004 from Gifu University in Japan. Prof. Liu was awarded the Advanced individuals in education and scientific research in Liaoning Province, Outstanding teachers in colleges and universities in Liaoning Province, and Excellent Science Workers in Liaoning Province.

As a project leader, he has presided over the funds of National Nature Science Foundation of China ‘The Role of Interaction Between H5N1 Avian Influenza Virus NS1 Protein and Human NOLC1 Protein in CK2-related Signaling Pathway and Infection Mechanism’ and ‘Study on Humanized Highly Pathogenic Avian Influenza Virus cDNA Prediction Probe Library’, and more than 30 other projects.

Major Research Areas:

Microbiology area. Influenza virus NS1 regulatory pathway, Nattokinase molecular modification and green and healthy fish farming.

Biological Health Statistics area. LncRNA-protein interaction prediction, protein-protein interaction, and protein interaction simulation, prediction of drug targets and toxicology.

Published Papers:

1) Huawei Feng, Li Zhang, Haixin Ai, Xingang Zhang, Shimeng Li, Tianzhou Yang, Jian Zhao, Mengyuan Qi, Hongsheng Liu (corresponding author). Ocular Bacterial signatures of Exophthamic Disease in Farmed Turbot (Scophthalmus maximus). Aqucutural Research. 2020. http://doi.org/10.1111/are.14574.

2) Hongsheng Liu, Guofei Ren, Haoyu Chen, Qi Liu, YingjuanYang, Qi Zhao (corresponding author). Predicting lncRNA-miRNA interactions based on logistic matrix factorization with neighborhood regularized. Knowledge-Based Systems. 2020. 191(2020):105261. https://doi.org/10.1016/j.knosys.2019.105261.

3) Hui Zhang, Zhong Ming, Chunlong Fan, Qi Zhao, Hongsheng Liu (corresponding author). A path-based computational model for long non-coding RNA-protein interaction prediction. Genomics. 2019.

4) Ming Zhang, Li Zhang, and Hongsheng Liu (corresponding author), A New Comprehensive Index for Evaluating the Quality of Infant Formula under the Framework of Chinese Food Standards. Current Bioinformatics, 2019. 14: p. 1-1.

5) Zimo Yin, Haixin Ai, Li Zhang, Guofei Ren, Yuming Wang, Qi Zhao, and Hongsheng Liu (corresponding author), Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints. Journal of Applied Toxicology, 2019. 39:1366–1377.

6) Haixin Ai, Xuewei Wu, Li Zhang, Mengyuan Qi, Ying Zhao, Qi Zhao, Jian Zhao, and Hongsheng Liu (corresponding author), QSAR modelling study of the bioconcentration factor and toxicity of organic compounds to aquatic organisms using machine learning and ensemble methods. Ecotoxicology and Environmental Safety, 2019. 179: p. 71-78.  

7) Junfeng Zhu, Ying Xu, Jian Zhao, Xue Li, Xinrui Meng, Tianqi Wang, Benyao Zou, Pengyan Zhao, Qi Liu, Changlong Lu, Fangliang Zheng, and Hongsheng Liu (corresponding author), IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response. Journal of Immunology Research, 2018: p. 1827901.

8) Qi Zhao, Dan Liang, Huan Hu, Guofei Ren, and Hongsheng Liu (corresponding author), RWLPAP: Random Walk for lncRNA-protein Associations Prediction. Protein & Peptide Letters, 2018. 25(9):830-837.

9) Qi Zhao, Haifan Yu, Zhong Ming, Huan Hu, Guofei Ren, and Hongsheng Liu (corresponding author), The Bipartite Network Projection-Recommended Algorithm for Predicting Long Non-coding RNA-Protein Interactions. Molecular Therapy - Nucleic Acids, 2018. 13: p. 464-471.

10) Qi Zhao, Yue Zhang, Huan Hu, Guofei Ren, Wen Zhang, and Hongsheng Liu (corresponding author), IRWNRLPI: Integrating Random Walk and Neighborhood Regularized Logistic Matrix Factorization for lncRNA-Protein Interaction Prediction. Frontiers in Genetics, 2018. 9(239).

11) Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao, and Hongsheng Liu (corresponding author), Applications of Machine Learning Methods in Drug Toxicity Prediction. Current topics in medicinal chemistry, 2018. 18(12): p. 987-997.

12) Liang Xu, Yanxi Hu, Yancheng Li, Li Zhang, Haixin Ai, Yufeng Liu, and Hongsheng Liu (corresponding author), In vitro DNA binding studies of lenalidomide using spectroscopic in combination with molecular docking techniques. Journal of Molecular Structure, 2018. 1154: p. 9-18.

13) Huan Hu, Li Zhang, Haixin Ai, Hui Zhang, Yetian Fan, Qi Zhao, and Hongsheng Liu (corresponding author), HLPI-Ensemble: Prediction of human lncRNA-protein interactions based on ensemble strategy. RNA biology, 2018. 15(6): p. 797-806.

14) Ai Haixin, Zhang Li, Zhang Jikuan, Cui Tong, K. Chang Alan, and Liu Hongsheng (corresponding author), Discrimination of Thermophilic and Mesophilic Proteins Using Support Vector Machine and Decision Tree. Current Proteomics, 2018. 15(5): p. 374-383.

15) Haixin Ai, Xuewei Wu, Mengyuan Qi, Li Zhang, Huan Hu, Qi Zhao, Jian Zhao, and Hongsheng Liu (corresponding author), Study on the Mechanisms of Active Compounds in Traditional Chinese Medicine for the Treatment of Influenza Virus by Virtual Screening. Interdisciplinary Sciences: Computational Life Sciences, 2018. 10(2): p. 320-328.

16) Haixin Ai, Wen Chen, Li Zhang, Liangchao Huang, Zimo Yin, Huan Hu, Qi Zhao, Jian Zhao, and Hongsheng Liu (corresponding author), Predicting drug-induced liver injury using ensemble learning methods and molecular fingerprints. Toxicological Sciences, 2018. 165(1): p. 100-107.

17) Chunyu Zhu, Fangliang Zheng, Junfeng Zhu, Meichen Liu, Na Liu, Xue Li, Li Zhang, Zaidong Deng, Qi Zhao, and Hongsheng Liu (corresponding author), The interaction between NOLC1 and IAV NS1 protein promotes host cell apoptosis and reduces virus replication. Oncotarget, 2017. 8(55): p. 94519-94527.

18) Liang Xu, Yanxi Hu, Yancheng Li, Yufeng Liu (corresponding author), Li Zhang, Haixin Ai, and Hongsheng Liu (corresponding author), Study on the interaction of paeoniflorin with human serum albumin (HSA) by spectroscopic and molecular docking techniques. Chemistry Central Journal, 2017. 11(1): p. 116.

19) Hongsheng Liu, Guofei Ren, Huan Hu, Li Zhang, Haixin Ai, Wen Zhang, Qi Zhao (corresponding author). LPI-NRLMF: LncRNA-protein Interaction Prediction by Neighborhood Regularized Logistic Matrix Factorization. Oncotarget. 2017.

20) Li Zhang, Haixin Ai, Shimeng Li, Mengyuan Qi, Jian Zhao, Qi Zhao, Hongsheng Liu (corresponding author). Virtual screening approach to identifying influenza virus neuraminidase inhibitors using molecular docking combined with machine-learning-based scoring function. Oncotarget. 2017, 8(47): 83142-83154.

21) Fangliang Zheng, Wenwen Zheng, Limei Li, Siming Pan, Meichen Liu, Weiwei Zhang, Hongsheng Liu (corresponding author), Chunyu Zhu (corresponding author). Chitosan Controls Postharvest Decay and Elicits Defense Response in Kiwifruit. Food and Bioprocess Technology. 2017, 10(11): 1937-1945.

22) Li Zhang, Haixin Ai, Wen Chen, Zimo Yin, Huan Hu, Junfeng Zhu, Jian Zhao, Qi Zhao, Hongsheng Liu (corresponding author). CarcinoPred-EL: Novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods. Scientific Reports. 2017. 7(1):2118.

23) Liang Xu, Yanxi Hu, Jin Li, Yufeng Liu (corresponding author), Li Zhang, Haixin Ai, Hongsheng Liu (corresponding author). Probing the binding reaction of cytarabine to human serum albumin using multispectroscopic techniques with the aid of molecular docking. Journal of Photochemistry and Photobiology B: Biology. 2017. 173:187-195.

24) Huan Hu, Chunyu Zhu, Haixin Ai, Li Zhang, Jian Zhao, Qi Zhao, Hongsheng Liu (corresponding author). LPI-ETSLP: lncRNA–protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction. Molecular BioSystems. 2017. 13(9):1781-1787.

25) Haixin Ai, Runlin Wu, Li Zhang, Xuewei Wu, Junchao Ma, Huan Hu, Liangchao Huang, Wen Chen, Jian Zhao, Hongsheng Liu (corresponding author). pSuc-PseRat: Predicting Lysine Succinylation in Proteins by Exploiting the Ratios of Sequence Coupling and Properties. Journal of Computational Biology. 2017. 24.

26) Li Zhang, Haixin Ai, Qi Zhao, Junfeng Zhu, Wen Chen, Xuewei Wu, Liangchao Huang, Zimo Yin, Jian Zhao, Hongsheng Liu (corresponding author). Computational Prediction of Influenza Neuraminidase Inhibitors Using Machine Learning Algorithms and Recursive Feature Elimination Method. Lecture Notes in Computer Science. 2017. 10330:344-349.

27) Hai-Xin Ai, Yu-Chen Che, Li Wang, Li Zhang, Ying Gu, Yan-Ni Tan, Alan K. Chang and Hong-Sheng Liu (corresponding author). Paenibacillus liaoningensis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology (2016), 66, 3150–3156.

28) Chunyu Zhu，Fangliang Zheng，Xiaoshuang She，Dan Zhao，Ying Gu，Yanting Duan，Alan K Chang，Hongsheng Liu(corresponding author). Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein. Virus genes. 2015, 50(2): 238-244.

29) Haixin Ai, Fangliang Zheng, Fangbo Deng, Chunyu Zhu, Ying Gu, Li Zhang, Xuejiao Li, Alan K. Chang, Jian Zhao, Junfeng Zhu, Hongsheng Liu(corresponding author). Structure-based virtual screening for potential inhibitors of influenza A virus RNA polymerase PA subunit. International Journal of Peptide Research and Therapeutics. 2015, 21(1): 149-156.

30) Haixin Ai, Li Zhang, Alan K. Chang, Hongyun Wei, Yuchen Che, Hongsheng Liu(corresponding author). 2014. Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus. Journal of molecular modeling. 2014, 20(3): 2142.

31) Fangliang Zheng, Nan Liu, Yuchen Che, Li Zhang, Lijie Shao, Junfeng Zhu, Jian Zhao, Haixin Ai, Alan K Chang, Hongsheng Liu(corresponding author). 2013. Cloning, expression and characterization of squalene synthase from Inonotus obliquus. Genes & Genomics. 2013, 35(5): 631-639.

32) Chunyu Zhu, Fangliang Zheng, Tingting Sun, Yanting Duan, Jingzhen Cao, Huawei Feng, Lingling Shang, Ying Zhu and Hongsheng Liu(corresponding author). Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1. Virus genes. 2013, 46(2): 287-292.

33) Chunyu Zhu, Tingting Sun, Jian Zhao, Ning Wang, Fangliang Zheng, Haixin Ai, Junfeng Zhu, Xiaoying Wang, Ying Zhu, Jianguo Wu, Hongsheng Liu(corresponding author). Screening of Proteins Interacting with Nonstructural 1 Protein of H5N1 Avian Influenza Virus from T7-phage Display Library. Chemical Research in Chinese Universities. 2012, 28(1): 103-107.

34) Li Zhang, Jian Zhao, Guowei Ding, Xuejiao Li, Hongsheng Liu(corresponding author). 2011. Screening of potent inhibitor of H1N1 influenza NS1 CPSF30 binding pocket by molecular docking. 2012, Advances in Infectious Diseases. 2, 92-96.  (2011 Int'l Conf. on Computational Biology and Bioinformatics. 601-604.)

35) Haixin Ai, Fangling Zheng, Chunyu Zhu, Tingting Sun, Liang Zhang, Xue Liu, Xuejiao Li, Guangyu Zhu, Hongsheng Liu(corresponding author). Discovery of novel influenza inhibitors targeting the interaction of dsRNA with the NS1 protein by structure-based virtual screening. International journal of bioinformatics research and applications. 2010, 6(5): 449-460.

36) Yana Song, Jing Hui, Wei Kou, Ru Xin, Fei Jia, Ning Wang, Fengqing Hu, Huili Zhang , Hongsheng Liu(corresponding author). Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides. Current microbiology. 2008, 57(5): 454-462.

37) Hongsheng Liu, Ying Li, Xinxiang Huang, Yoshiaki Kawamura, Takayuki Ezaki. 2003. Use of the dnaJ gene for the detection and identification of all Legionella pneumophila serogroups and description of the primers used to detect 16S rDNA gene sequences of major members of the genus Legionella. Microbiology and immunology. 2003, 47(11): 859-869.