CHEN Changlan, who is male and of Han nationality, was born in the august of 1963. He finished his undergraduate course from Department of Biology of Shandong University and doctoral course from Department of horticulture of Shenyang Agricultural University. He finished his post-doctoral experience from Institute of Genetics and Molecular Biology of Seoul National University. Now he is the professor and dean of School of Pharmaceutical Science of Liaoning University, the advisor of Master degree candidates, young and mid-aged core teacher of the university. He is also honored the member of council of the Genetic Association of Liaoning province, the member of council of the Ecological Association of Liaoning province, and the member of the teaching steering committee of pharmaceutical engineering in Liaoning province.
As a project host he has presided over the fund of national nature and science ‘The influence of selenoprotein SelK on the phagocytic and transfer ability of microglia and monocyte and the relationship of the protein with Alzheimer’s disease’ (2013) and ‘Studies on the cellular localization, topological structure and molecular functions of selenoprotein G-rich in Drosophila’ (2006), and more than 10 other national, provincial and municipal projects. He published more than 40 papers as a first author or a corresponding author inBiochemical and Biophysical Research Communications, Biochemistry (Moscow), Food Science and other journals at home and abroad. He took part and finished the writing of 3 compositions. Three patents for invention were obtained as a first author. Two achievements he participated got the honor of national scientific and technological second prize, 4 achievements got the honor of scientific and technological second or third prize of the Ministry of Agriculture and one achievement got the honor of scientific and technological second prize of Liaoning Province.
1. Major Research Areas:
(1) The screening of drugs resisting Alzheimer’s disease. Selecting active ingredients resist to Alzheimer’s disease from Chinese herbal medicine and other natural products and studying their resistance mechanism.
(2) The studies on the cellular localization, molecular functions of selenoprotein SelK, and the relationship of the protein with human diseases.
(3) The studies on the active ingredients of Cordyceps militaris and the mechanism of the active ingredients resist to cancer and improving human immunity.
2.Major Research Projects presided over:
(1) The fund of national nature and science 2013, ‘The influence of selenoprotein SelK on the phagocytic and transfer ability of microglia and monocyte and the relationship of the protein with Alzheimer’s disease’, No. 31371085.
(2) The fund of national nature and science 2006, ‘Studies on the cellular localization, topological structure and molecular functions of selenoprotein G-rich in Drosophila’ (2006), No. 30671136.
(3) The fund of scientific research of Department of Education of Liaoning Province 2013, ‘Studies on the shear state of selenoprotein SelK in microglia and the influence of the protein to the phagocytic and transfer ability of the cells’, No.L2013010.
(4) The fund of the key laboratory of Department of Education of Liaoning Province 2009, ‘Studies on the mass production technology of cordycepin by liquid fermentation culture.’ , No.2009S046.
3.Major Patents:
(1) The patent for invention, ‘The flash type extraction method of the active ingredients from Cordyceps militaris’ obtained the authorization from the National Patents Office in 2013. Patent No.ZL201210084854.3. First author.
(2) The patent for invention, ‘One method for the extraction and refining of cordycepin from the sporocarps ofCordyceps militaris’ obtained the authorization from the National Patents Office in 2014. Patent No.ZL201210084508.5. First author.
(3) The patent for invention, ‘The flash type extraction method of lotus plumule alkaloids’ obtained the application number from the National Patents Office in 2015. Patent No.ZL201511016484.0. First author.
4.Major Papers:
(1) Chen CL, Huan FN, Meng XL, Lv J, The effect of selenium on human health and diseases and the scientifically supplementation of selenium to human bodies. Journal of Liaoning University (Natural Sciences Edition), 2016, 43(2):155-168.
(2) Meng XL, Li C, Wang S, Chen C (Corresponding author), Research advances on the pharmacological effects of Bisbenzy-lisoquinoline alkaloids. Journal of Liaoning University (Natural Sciences Edition), 2016, 43(3):243-248.
(3) Chen LJ, Liu Y, Jia D, Yang J, Zhao J, Chen CL, Liu H, Liang X, Pharmacokinetics and Biodistribution of Aurantiamide and Aurantiamide Acetate in Rats after Oral Administration of ortulaca oleracea L. Extracts J Agric Food Chem 2016, 64(17):3445-55.
(4) Ben SB , Peng B, Wang GC , Li C , Gu HF, Jiang H, Meng XL, Lee BJ, Chen CL (Corresponding author), Overexpression of Selenoprotein SelK in BGC-823 Cells Inhibits Cell Adhesion and Migration. Biochemistry (Moscow), 2015, 80 (10): 1344-1353.
(5) Meng XL, Chen CL (Corresponding author), Kong WJ, ShanYH, Dai QC, Li D, Wang X, Fu X, Ben SB, Cordycepin Inhibits Microglial Activation Induced by Lipopolysaccharide and Provides Neuroprotection. Food Science, 2014, 35(19): 224-229
(6) Meng XL, Sun D, Ma J, Ben SB, Chen CL (Corresponding author), Study on the Conditions for the Production of Cordyceps Polysaccharide and Cordycepin by Cylinder Fermentation of Cordyceps Militaris，Journal of Liaoning University (Natural Sciences Edition), 2013, 40 (3): 260-265.
(7) Ben SB, Zhang Y, Sun D, Gu HF, Meng XL, Chen CL(Corresponding author), Healthcare Functions of Apple Cider Vinegar Fortified with Cordycepsmilitaris Polysaccharides Food Science，2014, 35（7）：232-237
(8) Ben SB, Li H, Huang Z, Sang Y, Meng C, Hou X, Mou T, Chen CL (Corresponding author), Amino Acid Addition Technology during Mycelium Fermentation of Cordyceps militaris. Food Science, 2010, 31(23),233-237.
(9)Chen CL,Meng CC, Tong L, Huang ZQ, Sang YL, Ma JQ, Hou X, Ben SB, Effects of Different Kinds of Amino Acids on Mycelial Growth and Cordycepin Content in Cordyceps militaris. Food Science，2012, 33（23）：236-239.
(10) Ben SB, Wang QY, Xia L, Xia JZ, Wang J, Bai H, Cui J, Shim MS, Lee BJ, Sun LG, Chen CL(Corresponding author), Selenoprotein dSelK in Drosophila Elevates the Release of Free Ca2+ from Endoplasmic Reticulum by Up-regulating the Expression of Inositol 1, 4, 5-tris-phosphate Receptor. Biochemistry (Moscow), 2011, Vol. 76 ( 9): 1030_1036.
(11) Gu Y, Mu T, Zhao S, Xia L, Xia JZ, Li JH, Deng XJ, Ben SB, Chen CL (Corresponding author), The Over-expression of Drosophila Selenoprotein dSelK in E. coli and the Purification. 2010 First International conference on Cellular, Molecular Biologyy, Biophysics and Bioengineering (CMBB2010)，889.
(12) Mu T, Wang QY, Xia L, Xia JZ, Deng XJ, Ben SB, Chen CL(Corresponding author), Studies on the cellular localization of three proteins in Drosophila melanogaster. 2010 First International conference on Cellular, Molecular Biologyy, Biophysics and Bioengineering (CMBB2010)，1065.
(13) Wang Y, Tie M, Kang PL, Lue YT, Ben SB, Chen CL（Corresponding author）, Comparison of ICP-MS and Two Other Analytical Methods for Determination of Selenium Content in Cordyceps Militaris Spectroscopy and Spectral Analysis 2009, 29(3), 815-818.
(14) Huang ZQ, Ben SB, Sang YL, Dai Y, Li H, Chen CL (Corresponding author), Extraction of Cordycepin from Fermented Mycelia of Cordyceps militaris: A Comparitive Study of Ultrasonic-assisted and Microwave-assisted Procedures. Food Science, 2009, 30 (18): 176-180.
(15)Ben SB, Huang ZQ, Wang Y, Hou X, Chen CL(Corresponding author), Optimization of Selenium Enrichment of Cordyceps militaris and Analysis of Effects of Selenium Enrichment on Contents of Two Major Active Components. Food Science ,2009，30(17): 266-269.
