Prof. MENG Xuelian obtains her B.Sc and master’s degree in Liaoning University in China, with emphasis on environmental science. Subsequently, she completes her Ph.D in pharmacology in Shenyang Pharmaceutical University in China. She has joined the School of Pharmaceutical Science, Liaoning University from 2008. The focus of her research is on the drug screening and mechanism of neurodegenerative diseases. To date, more than 50 scientific papers are published in peer-reviewed pharmaceutical journals.

 Academic backgroud:

B.Sc Liaoning University 2002

Master Liaoning University 2005

Ph.D Shenyang Pharmaceutical University 2008

 Career highlights:

Professor, School of Pharmaceutical Science, Liaoning University (2008– )

 Research highlights:

1.  Drug screening and mechanism of neurodegenerative diseases

2.  Pharmacology of anti-inflammatory and anticancer agents.

Projects:

1.  Mechanism of bisbenzylisoquinoline alkaloids on hyperactivation of microglia and macrophage. National Science Foundation for Young Scholars of China.

2.  Molecular mechanism of nine bisbenzylisoquinoline alkaloids on microglial activation by ROS/NF-κB pathway.  Project of Science and Technology Department of Liaoning Province.

3. Protective effects of 12 bisbenzylisoquinoline alkaloids on Aβ-induced PC12 cells injury and their anti-Alzheimer's disease effects by Ca^{2 +}-CaM/CaMKII signaling pathway. Project of Science and Technology Department of Liaoning Province.

4.Study on the structure-activity relationships of flavonoids inhibiting the activation of microglia. Project of Education Department of Liaoning Province.

Papers:

[1] Meng XL, Chen ML, Chen CL, Gao CC, Li C, Wang D, Liu HS, Xu CB. Bisbenzylisoquinoline alkaloids of lotus (Nelumbo nucifera Gaertn.) seed embryo inhibit lipopolysaccharide-induced macrophage activation via suppression of Ca²⁺-CaM/CaMKII pathway. Food and Agricultural Immunology. 2019, 30(1): 878–896.

[2] Meng XL, Chen CL, Liu YY, Su SJ, Gou JM, Huan FN, Wang D, Liu HS, Ben SB, Lu J. Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca²⁺ Level Resulted from the Up-Regulation of IP3R. Neuroscience. 2019, 406: 38-49.

 [3] Chen ML, Gou JM, Meng XL*, Chen CL, Liu XN. Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation. Pharmazie. 2019, 74: 606-610.

[4] Meng XL, Zheng LC, Liu J, Gao CC, Qiu MC, Liu YY, Lu J, Wang D, Chen CL. Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation. RSC Advances. 2017, 7: 18347-18357.

[5] Meng XL, Zhang HL, Feng LL, Chen ML, Liu YY, Yu X, Huan FN, Lu J, Wang D, Liu HS, Chen CL. Selenoprotein SelK increases the secretion of insulin from MIN6 β cells. RSC Advances, 2017, 7: 35038-35047.

[6] Ma XP, Li XZ, Li WL, Wang D, Xu CB, Meng XL*. Identification and characterization of a cold-adapted and halotolerant nitrobenzene-degrading bacterium. RSC Advances. 2015, 5: 80276-80282.

[7] Xu CB, Gu JL, Ma XP, Dong T, Meng XL*. Investigation on the interaction of pyrene with bovine serum albumin using spectroscopic methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2014，125：391-395.

[8] Meng XL, Yang JY, Chen GL, Wang LH, Zhang LJ, Wang S, Li J, Wu CF. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships. Chemico-Biological Interactions. 2008, 174: 51-59.

[9] Meng XL, Yang JY, Chen GL, Zhang LJ, Wang LH, Li J, Wang JM, Wu CF. RV09, a novel resveratrol analogue, inhibit NO and TNF-α production by LPS-activated microglia. International Immunopharmacology. 2008, 8: 1074-1082.

[10] Meng XL, Chen GL, Yang JY, Wang S, Wu CF, Wang JM. Inhibitory effect of a novel resveratrol derivative on nitric oxide production in lipopolysaccharide-activated microglia. Pharmazie, 2008, 63: 671-675.

Contacts:

School of Pharmaceutical Science, Liaoning University,

No.66 Chongshan Middle Road, Huanggu District, Shenyang 110036, Liaoning, China

Tel: 024-62202469

Fax: 024-62202469

Email: rubymxl@163.com